Formulation: A solid
Formal Name: 3-(α-L-arabinofuranosyloxy)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C20H18O11
Formula Weight: 434,4
Shelf life (days): 1460
CAS Number: 572-30-5
Notes: Avicularin is a flavonoid glycoside that has been found in R. sachalinensis and has diverse biological activities.{63271,63272,63273,63274,63275} It inhibits fatty acid synthase (FASN) and aldose reductase (IC50s = 6.15 and 19.05 µM for the chicken liver and human enzymes, respectively).{63271,63272} Avicularin scavenges DPPH and superoxide radicals, as well as inhibits copper-induced oxidation of LDL in cell-free assays (IC50s = 64.3, 6, and 3.8 µM, respectively).{63273} It inhibits LPS-induced increases in nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) production in RAW 264.7 macrophages when used at concentrations ranging from 30 to 300 µM.{63274} Avicularin (100 µg/ml) inhibits the proliferation, migration, and invasion of, as well as induces apoptosis and cell cycle arrest at the G0/G1 phase in, Huh7 hepatocellular carcinoma cells.{63275}
English
Deutsch
