Formulation: A crystalline solid
Formal Name: nonanedioic acid
Purity: ≥95%
Formula Markup: C9H16O4
Formula Weight: 188,2
Shelf life (days): 1460
CAS Number: 123-99-9
Notes: Azelaic acid is a naturally occurring and saturated dicarboxylic acid with diverse biological activities.{38830,38831,38832,38833,38834} It is a competitive inhibitor of tyrosinase, NADH dehydrogenase, succinic dehydrogenase, and reduced ubiquitinone:cytochrome C oxidoreductase in vitro.{38830,38831} Azelaic acid inhibits the growth and colony formation of B16 murine as well as HMB2 and SK32 human melanoma cells in a concentration-dependent manner but has no effect on CHO cells.{38832} It decreases DNA synthesis, induces mitochondrial damage and dilation of the rough endoplasmic reticulum (RER), and reduces growth of mouse keratinocytes in a dose- and time-dependent manner.{38833} Azelaic acid is bacteriostatic against S. epidermidis, S. aureus, S. capitis, P. acnes, P. avidum, P. mirabilis, and C. albicans in vitro (MICs = 0.03-0.25 M).{38834} Formulations containing azelaic acid have been used in the treatment of acne and hyperpigmentation disorders.
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