Formulation: A solid
Formal Name: (3S,7S,11E)-3,4,5,6,7,8,9,10-octahydro-7,14,16-trihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1-one
Purity: ≥98%
Formula Markup: C18H24O5
Formula Weight: 320,4
Shelf life (days): 1460
CAS Number: 71030-11-0
Notes: β-Zearalenol is a mycotoxin, an agonist of estrogen receptor α (ERα), and an active metabolite of zearalenone (Item No. 11353).{27394,31434} β-Zearalenol increases the proliferation of MCF-7 cells that endogenously express ERα (EC50 = 8.49 nM).{31434} It is also an androgen receptor antagonist (IC50 = 23.10 µM for the human receptor). β-Zearalenol (100 µM) decreases path and straight line velocity and cell linearity, as well as increases curvilinear velocity and the levels of acrosome-reacted sperm, in isolated stallion sperm.{27396} α-Zearalenol induces cytotoxicity in isolated phorbol 12-myristate 13-acetate-stimulated pig neutrophils (IC50 = 56.8 µM). It increases intracellular superoxide levels when used at a concentration of 1 µM, and decreases IL-8 supernatant levels in in the same cells at 10 µM.{69470} β-Zearalenol (50 mg/kg) increases uterine weight in immature female mice.{27394}
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