Betulinic Acid, CAS 472-15-1

Formulation: A solid

Formal Name: 3β-hydroxy-lup-20(29)-en-28-oic acid

Purity: ≥97%

Formula Markup: C30H48O3

Formula Weight: 456,7

Shelf life (days): 1460

CAS Number: 472-15-1

Notes: Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.{24274,24272,24270} Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.{24273} It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.{24270,22046}

• SKU: CAY11686-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 11686-500
• Green Labware: No
• Package Unit: 500 mg
• Quantity Unit: STK