Formulation: A crystalline solid
Formal Name: 5,7-dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C16H12O5
Formula Weight: 284,3
Shelf life (days): 1460
CAS Number: 491-80-5
Notes: Biochanin A is a natural isoflavone with diverse biological actions, most notably as a phytoestrogen. It can affect hormone levels by inhibiting 5α-reductase and 17β-hydroxysteroid dehydrogenase or altering aromatase (CYP19A1) activity.{12555,27057} Also known as 4’-methyl genistein, biochanin A can be metabolized in vivo to genistein (Item No. 10005167), another phytoestrogen with diverse effects.{22968} Biochanin A also intersects with signaling through peroxisome proliferator-activated receptors (PPARs), as it activates PPARγ (EC50 = 19 µM) and has also been shown to activate a PPARα promoter.{27056} Moreover, it increases the expression of the PPARγ coactivator PGC-1α, promoting mitochondrial biogenesis.{16120} Biochanin A also inhibits fatty acid amide hydrolase (IC50 = 2.4 µM) and acts as an agonist of the aryl hydrocarbon receptor (EC50 = 0.25 µM).{27055,27054}
English
Deutsch
