Formulation: A lyophilisate
Formal Name: 20-(carboxymethyl)-6R-methoxy-2,5,17S-trimethyl-2E,4Z,8Z,10E,14E,18E,20Z-docosaheptaenedioic acid
Purity: ≥98%
Formula Markup: C28H38O7
Formula Weight: 486,6
Shelf life (days): 1460
CAS Number: 11076-19-0
Notes: Bongkrekic acid is polyketide and bacterial toxin that has been found in B. gladioli.{30508,68268} It is an inhibitor of ADP/ATP translocase (AAT), a carrier protein that imports ADP into the mitochondrial matrix and exports ATP into the intermembrane space.{30508,68267} It prevents ADP import and inhibits mitochondrial respiration (Ki = 20 nM in isolated rat liver mitochondria).{68269,68270} Bongkrekic acid induces cell death in MCF-7 human breast cancer cells deprived of estradiol for six months (EC50 = 2.58 µM).{68271} It is toxic to mice (LD50s = 0.68-6.84 mg/kg, p.o.).{68272}
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