Formulation: A liquid
Purity: ≥98% deuterated forms (d1-d7)
Formula Markup: C4HD7O2
Formula Weight: 95,1
Shelf life (days): 730
CAS Number: 73607-83-7
Notes: Butyric acid-d7 is intended for use as an internal standard for the quantification of sodium butyrate (Item No. 13121) by GC- or LC-MS. Butyric acid is a short-chain fatty acid.{52278} It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk.{52278,52279} Butyric acid is an inhibitor of histone deacetylase (HDAC; IC50 = 90 µM in a cell-free assay).{52280} It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM.{52279,52281,17300,52282} Butyric acid decreases the expression of IFN-γ-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM.{17300} It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day.{52281} Butyric acid also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.{52283}
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