Formulation: A solid
Formal Name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide-18,18,18-d3
Purity: ≥99% deuterated forms (d1-d3); ≤1% d0
Formula Markup: C36H70D3NO3
Formula Weight: 571
Shelf life (days): 730
CAS Number: 2699606-99-8
Notes: C18 dihydro Ceramide-d3 is intended for use as an internal standard for the quantification of C18 dihydro ceramide (d18:0/18:0) (Item No. 24379) by GC- or LC-MS. C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide (d18:1/18:0) (Item No. 19556) that lacks the 4,5-trans double bond.{40697} Increased C18 dihydro ceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers α-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes.{40698} It is also elevated in the skin of patients with lesional atopic dermatitis.{40696}
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