Formulation: A solid
Formal Name: N-[(1S,2R,3E)-1-[[[O-(N-acetyl-α-neuraminosyl)-(2→8)-O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-octadecanamide-18,18,18-d3, diammonium salt
Purity: ≥99% deuterated forms (d1 -d3)
Formula Markup: C70H120D3N3O29 • 2NH4
Formula Weight: 1509,8
Shelf life (days): 1460
CAS Number: 2692624-24-9
Notes: C18 Ganglioside GD3-d3 is intended for use as an internal standard in the quantification of ganglioside GD3 (Item No. 17481) by GC- or LC-MS. Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide (Item No. 16983) and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.{28470} Furthermore, the intracellular accumulation of ganglioside GD3 can contribute to mitochondrial damage, a crucial event during apoptosis.{5033} Ganglioside GD3 has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.{28470,28471} As this product is derived from a natural source, there may also be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 2054]
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