Formulation: A film
Formal Name: N-[(1S,2R,3E)-1-[[[O-(N-acetyl-α-neuraminosyl)-(2→3)-O-β-D-galactopyranosyl-(1→4)-β-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-octadecanamide-18,18,18-d3, monoammonium salt
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C59H104D3N2O21 • NH4
Formula Weight: 1201,6
Shelf life (days): 1095
CAS Number: 2692623-85-9
Notes: C18 Ganglioside GM3-d3 (d18:1/18:0-d3) is intended for use as an internal standard for the quantification of ganglioside GM3 (Item No. 15587) by GC- or LC-MS. Ganglioside GM3 is a simple monosialoganglioside that demonstrates both antiproliferative and proapoptotic effects in tumor cells by modulating cell adhesion, proliferation, and differentiation.{25490,25485} When used at a concentration of 20 μM, it suppresses angiogenesis and reduces endothelial cell proliferation and migration by inhibiting VEGFR2 and Akt phosphorylation.{25490} Furthermore, ganglioside GM3 has been shown to induce the dissociation of the insulin receptor-caveolin-1 complex from lipid microdomains, functioning as an inhibitor of insulin signaling and contributing to insulin resistance.{25481}
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