Formulation: A solid
Formal Name: N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-acetamide
Purity: ≥98%
Formula Markup: C20H41NO4
Formula Weight: 359,6
Shelf life (days): 1460
CAS Number: 21830-28-4
Notes: C2 Phytoceramide is a bioactive semisynthetic sphingolipid that inhibits formyl peptide-induced oxidant release (IC50 = 0.38 µM) in suspended polymorphonuclear cells.{39106} It increases COX-2 protein levels 15-fold through ERK signaling.{39104} It induces death of keratinocytes (20% viability) with an ED50 value of 30 µM, the same concentration at which 35% of cells in a TUNEL assay are apoptotic. C2 Phytoceramide also has antiproliferative effects in CHO cells, with greater than 80% cytotoxicity achieved at a concentration of 20 µM, and induces internucleosomal DNA fragmentation.{39105} In addition, it inhibits the activation of phospholipase D (PLD) mediated by muscarinic acetylcholine receptors in vitro. [Matreya, LLC. Catalog No. 1897]
English
Deutsch
