C22 Ceramide (d18:1/22:0), CAS 27888-44-4

Formulation: A crystalline solid

Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-docosanamide

Purity: ≥95%

Formula Markup: C40H79NO3

Formula Weight: 622,1

Shelf life (days): 730

CAS Number: 27888-44-4

Notes: C22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway.{37099} C22 ceramide forms small channels in liposomes, whereas C16 ceramide (Item No. 10681) forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.{37098}

• SKU: CAY22533-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 22533-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK