Formulation: A solution in methanol
Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-15,15,16,16,17,17,17-d7]-hexanamide
Purity: ≥99% deuterated forms (d1-d7)
Formula Markup: C24H40D7NO3
Formula Weight: 404,7
Shelf life (days): 730
CAS Number: 2692624-22-7
Notes: C6 Ceramide-d7 is intended for use as an internal standard for the quantification of short-chain ceramides, such as C2 ceramide (Item Nos. 62510 / 24386 / 24387), C6 ceramide (Item No. 62525), and C8 ceramide (Item Nos. 62540 / 24391 / 24392), by GC- or LC-MS. C6 Ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides.{2756} C6 Ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain.{2756,3988,2757,5031} It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells.{5473,3512} C6 Ceramide acts in neuronal axons to inhibit neurite growth.{5302}
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