Formulation: A solid
Formal Name: N-[(1S,2S,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-octanamide
Purity: ≥98%
Formula Markup: C26H51NO3
Formula Weight: 425,7
Shelf life (days): 1460
CAS Number: 175892-44-1
Notes: C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides.{5258} It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide (Item No. 24391), induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide (Item No. 62540).{38647,5258} C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.{40652} [Matreya, LLC. Catalog No. 1830]