Formulation: A solution in methanol
Formal Name: 16-[[(ethylamino)carbonyl]amino]-11Z-hexadecenoic acid
Purity: ≥98%
Formula Markup: C19H36N2O3
Formula Weight: 340,5
Shelf life (days): 730
CAS Number: 1184844-74-3
Notes: 17(R),18(S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EpETE), a natural cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid, is known to reduce the contraction rate of spontaneously beating heart cells and to protect neonatal rat cardiomyocytes against arrhythmias induced by β-adrenergic agonists (EC50 = ~ 1-2 nM).{19905} CAY10662 is a 1,3 disubstituted urea derivative of 17(R),18(S)-EpETE that is more metabolically robust and reduces the contractility of cardiomyocytes with improved potency (EC50 fold higher than required for the effect on cardiomyocytes, 1-5 μM CAY10662 exerts weak dose-dependent soluble epoxide hydrolase inhibition.{19905}
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