Formulation: A solid
Purity: ≥98%
Formula Markup: C43H87N2O6P (for tricosanoyl)
Formula Weight: 759,2
Shelf life (days): 1460
Notes: Ceramide phosphoethanolamine (CPE) is an analog of sphingomyelin that contains ethanolamine rather than choline as the head group. It is the principal membrane phospholipid in invertebrates such as Drosophila, which lacks sphingomyelin.{36593} It is only produced in small amounts in mammalian cells, accounting for approximately 0.02 mol% of total phospholipids in mouse testis and brain.{36594} In Drosophila, CPE is biosynthesized by CPE synthase from ceramide and cytidine diphosphate-ethanolamine in the Golgi lumen. In mammals, it is biosynthesized by sphingomyelin synthase 2 (SMS2) in the plasma membrane and by sphingomyelin synthase-related protein (SMSr) in the endoplasmic reticulum (ER).{36593} In Drosophila, CPE has a role in glial ensheathment of axons.{36595} Disrupting CPE synthesis by depleting SMSr in vitro in mammalian cells leads to an accumulation of ER ceramides, which are then mislocalized to the mitochondria, inducing apoptosis.{36596} However, ceramide levels are not altered in transgenic mice lacking SMSr catalytic activity.{36594} This product contains ceramide phosphoethanolamine molecular species with primarily C23:0, C24:0, and C21:0 fatty acyl chains. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1327]
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