Formulation: A solid
Formal Name: (4S,4aS,5aS,6S,12aS)-7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
Purity: ≥98%
Formula Markup: C22H23ClN2O8
Formula Weight: 478,9
Shelf life (days): 1460
CAS Number: 57-62-5
Notes: Chlortetracycline is a broad-spectrum antibiotic originally isolated from S. aureofaciens.{36361,36363} It inhibits growth of both Gram-positive and Gram-negative bacteria at a range of 0.1-100 μg/ml against A. aerogenes, D. pneumoniae, E. coli, K. pneumoniae, P. morganii, and several species of Haemophilus, Neisseria, Salmonella, and Staphylococcus.{36363} Chlortetracycline protects mice from infection by various strains of S. aureus with protective doses (PD50s) of 0.2-7.5 mg/kg, and from infection by E. coli (PD50 = 3 mg/kg) and K. pneumoniae (PD50 = 75 mg/kg).{36362} It acts by inhibiting protein synthesis, and it binds to a single site on the 30S ribosome subunit.{36361} Chlortetracycline is an ionophore and is selective for calcium over sodium, potassium, magnesium, strontium, and barium.{36364} It transports calcium from an aqueous phase into an organic phase environment or into multilamellar vesicles. Chlortetracycline is also a fluorescent dye that can be used to monitor calcium flux.{36365}
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