Cholestenone, CAS 601-57-0

Formulation: A crystalline solid

Formal Name: cholest-4-en-3-one

Purity: ≥95%

Formula Markup: C27H44O

Formula Weight: 384,6

Shelf life (days): 1460

CAS Number: 601-57-0

Notes: Cholestanone is a cholesterol metabolite that has a keto group in place of the 3-hydroxy group on cholesterol.{48122} It decreases TGF-β-induced Smad2 phosphorylation and TGF-β expression and prevents inhibition of DNA synthesis by TGF-β in Mv1Lu cells when used at a concentration of 50 µg/ml.{48123} Increased fecal excretion of cholestenone is correlated with an increased risk of colorectal cancer. Cholestenone reduces serum cholesterol levels in a variety of animal models but is toxic to rats when administered at doses of 700-1,000 mg/kg per day, inducing hypertrophy in and reducing the activity of the adrenal gland.{48124} It has been used as synthetic intermediate in the synthesis of steroids.{48125}

• SKU: CAY25713-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 25713-10
• Green Labware: No
• Package Unit: 10 g
• Quantity Unit: STK