Formulation: A solution in methyl acetate
Formal Name: (3β)-cholest-5-en-3-ol-d8 3-[(5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoate]
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C47H68D8O2
Formula Weight: 681,2
Shelf life (days): 730
Notes: Cholesteryl arachidonate-d8 is intended for use as an internal standard for the quantification of cholesteryl arachidonate (Item No. 22595) by GC- or LC-MS. Cholesteryl arachidonate is a cholesterol ester that is found in plasma and the adrenal gland.{42068} It is a component of low-density lipoprotein (LDL) and oxidation of the arachidonate moiety contributes to macrophage activation and foam cell formation in atherosclerosis.{42069} Cholesteryl arachidonate undergoes hydrolysis to release arachidonic acid during ACTH-stimulated prostaglandin synthesis in rat adrenocortical cells.{42070} Levels of cholesteryl arachidonate are increased in the bronchoalveolar lavage fluid (BALF) in pediatric cystic fibrosis patients compared to healthy controls as well as in placentas of women with chorioamnionitis.{42071,42072}
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