Cholesteryl Linoleate Hydroperoxides

Formulation: A solution in ethanol

Formal Name: (±)-9-hydroperoxy-10E,12Z-octadecadienoic acid, cholesteryl ester; (±)-13-hydroperoxy-9Z,11E-octadecadienoic acid, cholesteryl ester

Purity: ≥98% hydroperoxide content

Formula Markup: C45H76O4

Formula Weight: 681,1

Shelf life (days): 180

Notes: Cholesteryl linoleate hydroperoxides are derived from the autoxidation of cholesteryl linoleate and contain a mixture of racemic 9- and 13-HpODE cholesteryl esters. Oxidative modification of LDL is suggested to play an important role in atherosclerosis. (±)9- and (±)13-HODE cholesteryl esters were originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.{2227,2228} Later studies determined that 15-LO, from rabbit reticulocytes and activated human monocytes, oxygenates cholesteryl linoleate to both 9- and 13-hydroperoxy linoleate cholesteryl esters.{1126,2412} Cholesteryl ester hydroperoxides may be transferred from LDL to HDL, reduced to the corresponding hydroxides, and cleared via the liver.{6527,3832}

• SKU: CAY48001-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 48001-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK