Formulation: A crystalline solid
Formal Name: 16α,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11β-hydroxy-21-(2-methyl-1-oxopropoxy)-pregna-1,4-diene-3,20-dione
Purity: ≥98%
Formula Markup: C32H44O7
Formula Weight: 540,7
Shelf life (days): 1460
CAS Number: 126544-47-6
Notes: Ciclesonide (CIC) is a prodrug form of the glucocorticoid receptor agonist desisobutyryl-CIC (des-CIC).{29504} CIC binds to the glucocorticoid receptor with a Ki value of 37 nM.{29502} It is selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors. CIC inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation. Formulations containing CIC have been used in the maintenance treatment of asthma and in the treatment of allergic rhinitis.
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