Formulation: A crystalline solid
Formal Name: 21-(acetyloxy)-17-hydroxy-pregn-4-ene-3,11,20-trione
Purity: ≥98%
Formula Markup: C23H30O6
Formula Weight: 402,5
Shelf life (days): 1460
CAS Number: 50-04-4
Notes: Cortisone acetate is a synthetic glucocorticoid with anti-inflammatory properties.{40677} It decreases the size of Bacillus Calmette-Guérin (BCG) vaccine-induced dermal lesions and tuberculin reactions in rabbits when administered at 2 mg/kg on alternate days over the course of 46 days. It also reduces the number and percentage of activated lesion-infiltrating mononuclear cells and decreases the amount of caseous necrosis and ulceration. Cortisone acetate (2.5 mg/kg per day, s.c.) slows tissue regeneration in a rabbit model of wound healing.{40678} It also decreases the number of dexamethasone binding sites on isolated human lymphocytes by 30%.{40679} Formulations containing cortisone acetate have been used to relieve inflammation, pruritic manifestations of corticosteroid-responsive dermatoses, and in the treatment of immune and allergic disorders.
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