Formulation: A crystalline solid
Formal Name: 3,9-dihydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
Purity: ≥98%
Formula Markup: C15H8O5
Formula Weight: 268,2
Shelf life (days): 1460
CAS Number: 479-13-0
Notes: Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, Item No. 10006315) binds the estrogen receptors ERα (IC50 = 11 nM) and ERβ (IC50 = 2 nM) and can induce ER-dependent gene expression in isolated cells.{22350,22351} Coumestrol is also a weak antagonist of pregnane X receptor (IC50 = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC50 = 30 μM).{22352}