Formulation: A solution in ethanol
Formal Name: 2-[(2-pentylcyclopropyl)methyl]-cyclopropaneoctanoic acid
Purity: ≥95%
Formula Markup: C20H36O2
Formula Weight: 308,5
Shelf life (days): 730
CAS Number: 28399-31-7
Notes: DCP-LA is a derivative of linoleic acid (Item No. 90150) and a potent activator of PKCε.{41891} It activates PKCε with a greater than 7-fold stronger potency over PKCα, βI, βII, γ, δ, μ, η, and ζ in a cell-free assay. DCP-LA activates PKC in PC12 cells in a concentration-dependent manner, an effect that is blocked by the PCK inhibitor bisindolylmaleimide I (Item Nos. 13298 / 21180) and a PCKε-selective peptide inhibitor. It decreases intracellular levels of amyloid-β (Aβ) in Neuro2 neuroblastoma cells transfected with human APPSwe/PS1Δ9.{41892} DCP-LA also stimulates hippocampal glutamate release, striatal dopamine release, and hypothalamic serotonin release in rat brain slices in a PKC- and α7-containing nicotinic acetylcholine receptor-dependent manner.{41893} In vivo, DCP-LA (3 mg/kg, i.p.) prevents synaptic loss and amyloid plaque formation and decreases escape latency in the Morris water maze in the 5XFAD transgenic mouse model of Alzheimer's disease.{41894}
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