Formulation: A crystalline solid
Formal Name: 1,3,8,9-tetrahydroxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
Purity: ≥98%
Formula Markup: C15H8O7
Formula Weight: 300,2
Shelf life (days): 1460
CAS Number: 6468-55-9
Notes: Demethylwedelolactone (DWL) is a coumestan, originally isolated from E. alba, with diverse biological activities.{40154,40155,40156,40157} It reduces cytotoxicity induced by CCL4 and galactosamine (GaIN; Item No. 22981) in rat hepatocytes in a dose-dependent manner.{40154} DWL inhibits trypsin with an IC50 value of 3.0 μg/ml in vitro.{40155} It is the major constituent in purified butanolic extracts of E. prostrata which inhibit lethal and hemorrhagic activities of C. rhodostoma venom.{40156} DWL also inhibits anchorage-independent cell growth of MDA-MB-231 breast cancer cells and decreases the number of lung metastases in an MDA-MB-231 xenograft model in nude mice.{40157}
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