Formulation: A solid
Formal Name: 9-fluoro-11β,21-dihydroxy-16α-methyl-pregna-1,4-diene-3,20-dione-d3
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C22H26D3FO4
Formula Weight: 379,5
Shelf life (days): 1460
Notes: Desoximetasone-d3 is intended for use as an internal standard for the quantification of desoximetasone (Item No. 23945) by GC- or LC-MS. Desoximetasone is a glucocorticoid.{39559} In vivo, desoximetasone (0.001-0.1 mg) reverses increases in epidermal cell proliferation induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in SENCAR mice when administered topically. It also reduces TPA-induced expression of IL-6, COX-2, iNOS, and c-Jun mRNA levels in the skin of SENCAR mice, indicating anti-inflammatory action. Formulations containing desoximetasone have been used in the treatment of psoriasis and atopic dermatitis.
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