Formulation: A crystalline solid
Formal Name: (11β,16α)-9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione, disodium salt
Purity: ≥95%
Formula Markup: C22H28FO8P • 2Na
Formula Weight: 516,4
Shelf life (days): 1460
CAS Number: 2392-39-4
Notes: Dexamethasone phosphate is a glucocorticoid.{64722} It reduces LPS-induced production of RANTES, TGF-β1, and nitric oxide (NO) in BV-2 microglia when used at concentrations ranging from 1 to 4 µM. Dexamethasone phosphate reverses LPS-induced decreases in IL-10 levels in, and inhibits LPS-induced migration of, BV-2 microglia when used at a concentration of 4 µM. In vivo, dexamethasone phosphate decreases motor activity and reduces adrenal weight and plasma corticosterone levels in rats when administered in the drinking water at a concentration of 5 µg/ml.{64723} Dexamethasone phosphate (1.6 mg/kg per day) reduces joint swelling in a rat model of collagen-induced arthritis when administered for a minimum of seven days.{64724} It also reduces pruritis and the clinical lesion score in cats with hypersensitivity dermatitis.{64725} Formulations containing dexamethasone phosphate have been used in the treatment of various inflammatory diseases, arthritis, and endocrine disorders.
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