Formulation: A crystalline solid
Formal Name: 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid
Purity: ≥98%
Formula Markup: C19H12O8
Formula Weight: 368,3
Shelf life (days): 1460
CAS Number: 13739-02-1
Notes: Diacerein is a prodrug form of the anthraquinone derivative rhein (Item No. 17345).{65008} It inhibits RANKL- and IL-1β-induced differentiation of RAW 264.7 cells into osteoclasts when used at a concentration of 20 µg/ml.{25635} Diacerein (20 µg/ml) reduces levels of interleukin-1β-converting enzyme (ICE), also known as caspase-1, as well as IL-1β, and IL-18 in the superficial zone of human osteoarthritic cartilage explants.{65009} It decreases carrageenan-, dextran-, or zymosan-induced paw edema in rats when administered at a dose of 100 mg/kg.{65010}