Formulation: A crystalline solid
Formal Name: 5-[2-(4-hydroxyphenyl)ethyl]-1,3-benzenediol
Purity: ≥98%
Formula Markup: C14H14O3
Formula Weight: 230,3
Shelf life (days): 730
CAS Number: 58436-28-5
Notes: Dihydroresveratrol is a polyketide synthase-derived bibenzyl that has been found in C. sativa and has diverse biological activities.{62635,17409,62636,62637} It is also an active metabolite of resveratrol (Item Nos. 70675 / 10004235) that is formed by gut microbiota.{31380} Dihydroresveratrol inhibits DNA polymerase α but not DNA polymerase δ (Kis =29.3 and >100 µM, respectively) and the formation of thiobarbituric acid reactive substances (TBARS) in rat liver microsomes (EC50 = 1.57 µM).{17409} It stimulates the proliferation of hormone-sensitive MCF-7 breast cancer cells but not hormone-resistant MDA-MB-231 and BT474 breast cancer cells when used at concentrations ranging from 0.01 pM to 100 nM.{62636} Dihydroresveratrol decreases interalveolar septal thickness and alveolar hemorrhage in a rat model of lung injury induced by cerulein- and LPS-stimulated pancreatitis when administered at a dose of 50 mg/kg.{62637}
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