Formulation: A solid
Formal Name: (9Z,12Z)-9,12-octadecadienoic acid, 32-[[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-14,14,15,15,16,16,17,17,17-d9]amino]-32-oxodotriacontyl ester
Purity: ≥99% deuterated forms (d1-d9)
Formula Markup: C68H120D9NO5
Formula Weight: 1049,8
Shelf life (days): 1460
CAS Number: 2692624-26-1
Notes: EOS-d9 (d18:1-d9/32:0/18:2) is intended for use as an internal standard for the quantification of EOS (Item No. 22442) by GC- or LC-MS. EOS is a ceramide found in the outer layer of the epidermis in mammals.{34500} It is comprised of an ω-hydroxy very long-chain fatty acid (C28-36) esterified to the essential fatty acid linoleic acid (Item No. 90150) and glucosylated to sphingosine. The consecutive regio- and stereospecific oxygenation of the linoleate portion of EOS by 12(R)-lipoxygenase (12(R)-LO) and eLOX3 is essential for the maintenance of the epidermal barrier to prevent water loss. Following oxygenation, the oxidized linoleate is hydrolyzed, leaving the ω-hydroxy end of the very long-chain fatty acid to covalently bind the protein layer, forming the corneocyte lipid envelope and sealing the gap between the extracellular lipid lamellae and the cornified cell envelope of the corneocyte. [Matreya, LLC. Catalog No. 2208]
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