Formulation: A crystalline solid
Formal Name: (1S,16R)-7S,11S-dihydroxy-8,8,10R,12S-tetramethyl-3S-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Purity: ≥95%
Formula Markup: C26H39NO6S
Formula Weight: 493,7
Shelf life (days): 1460
CAS Number: 152044-53-6
Notes: Epothilone A (Epo A) is a biologically active macrolide produced from the fermentation of the soil bacteria S. cellulosum that was discovered as a potent antimicrotubule agent.{26908,19711,19714} In competition assays, epo A binds to β-tubulin with a similar order of magnitude as the binding of paclitaxel (Item No. 10461) to β-tubulin (IC50s = 2.3 and 3.6 µM, respectively).{26908,19711,19714,19713} Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B (Item No. 10924).{26908}
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