Formulation: A solid
Formal Name: (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-oxacyclohexadec-13-ene-2,6-dione
Purity: ≥95%
Formula Markup: C27H41NO5S
Formula Weight: 491,7
Shelf life (days): 1460
CAS Number: 189453-10-9
Notes: Epothilones are microtubule-stabilizing agents with potential anti-neoplastic actions.{19711,19714,26908} They are natural macrolides that have high potency in both taxane-sensitive and taxane-resistant models.{19714,26908} Epothilone D is a desoxy form of epothilone B (Item No. 10924) that inhibits the growth of a variety of cancer cells both in vitro (IC50 values range from 0.97 to 21 nM) and in mice.{26908,30210} Epothilone D is brain penetrant and reduces neurodegeneration in aged tau transgenic mice.{30209,30212} Effects include improved axonal transport, decreased tau neuropathology, and reduced hippocampal neuron loss.{30209,30212} Epothilone D also rescues microtubule defects and attenuates nigrostriatal degeneration in a mouse model of Parkinson’s disease.{30210}
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