Formulation: A crystalline solid
Formal Name: estra-1,3,5(10)-triene-3,15α,16α,17β-tetrol, hydrate
Purity: ≥95%
Formula Markup: C18H24O4 • XH2O
Formula Weight: 304,4
Shelf life (days): 1460
Notes: Estetrol is an estrogen steroid hormone exclusively produced by fetal liver from estradiol (Item No. 10006315) and estriol (Item No. 10006484) during pregnancy. It binds to estrogen receptors (ERs) with 4-fold higher affinity for ERα over ERβ and exhibits estrogenic effects in most tissues expressing ERs (bone, brain, vagina, and endometrium).{29396,29397} In breast tumors, however, estetrol acts as an estrogen antagonist in the presence of estradiol, preventing tumor growth.{29396,29397}