Formulation: A crystalline solid
Formal Name: estra-1,3,5(10)-triene-3,17-diol (17β)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
Purity: ≥95%
Formula Markup: C23H30Cl2NO6P • 2Na
Formula Weight: 564,3
Shelf life (days): 1460
CAS Number: 52205-73-9
Notes: Estramustine phosphate is a derivative of estradiol (Item Nos. 20776 / 10006315) that contains a nor-nitrogen mustard group. Estramustine phosphate destabilizes microtubules by binding to microtubule-associated proteins (MAPs) with Kd values of 10 and 15 µM for MAP-1 and MAP-2, respectively.{41153} Estramustine induces cell cycle arrest in mitosis at the metaphase stage in DU145 and PC3 prostate cancer cells and induces apoptosis in U87MG human malignant glioma cells.{41150,41151} The metabolites of estramustine phosphate have anti-androgenic effects.{41152} Formulations containing estramustine phosphate are used in the palliative treatment of prostate cancer.
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