Finasteride, CAS 98319-26-7

Finasteride, CAS 98319-26-7
SKU
CAY14938-100
Packaging Unit
100 mg
Manufacturer
Cayman Chemical

Availability: loading...
Price is loading...
Formulation: A crystalline solid

Formal Name: (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-(1,1-dimethylethyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-4a,6a-dimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide

Purity: ≥95%

Formula Markup: C23H36N2O2

Formula Weight: 372,5

Shelf life (days): 1460

CAS Number: 98319-26-7

Notes: Finasteride is a 4-azasteroid competitive inhibitor of 5α-reductase type II (IC50 = 4.2 nM) and a derivative of testosterone.{23862} It is 100-fold selective for 5α-reductase type II over type I. Finasteride (10 µM) does not affect the growth of androgen-refractory PC3 prostate cancer cells but increases the protein levels of Nrf2 and heme oxygenase-1 (HO-1).{23866} It decreases prostatic diameter and volume, as well as dihydrotestosterone, but not testosterone, serum levels in dogs with spontaneous benign prostatic hypertrophy when administered at doses of 0.1 and 0.5 mg/kg.{48477} Finasteride reduces testosterone-induced type I procollagen and TGF-β1 protein levels in cultured human scalp dermal fibroblasts in a model of androgenic alopecia when applied at a concentration of 0.1 μM.{23865} Formulations containing finasteride have been used in the treatment of benign prostatic hyperplasia and androgenic alopecia in men.
More Information
SKU CAY14938-100
Manufacturer Cayman Chemical
Manufacturer SKU 14938-100
Green Labware No
Package Unit 100 mg
Quantity Unit STK
Product information (PDF) Download
MSDS (PDF) Download