Formulation: A solution in ethanol
Formal Name: 7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]cyclopentyl]-5Z-heptenoic acid, 1-methylethyl ester
Purity: ≥98%
Formula Markup: C26H35F3O6
Formula Weight: 500,6
Shelf life (days): 730
CAS Number: 157283-68-6
Notes: Fluprostenol isopropyl ester is an analog of prostaglandin F2α (PGF2α; Item Nos. 16010 / 16020) and an isopropyl ester prodrug form of (+)-fluprostenol (Item No. 16768).{8839,9613} Fluprostenol isopropyl ester is an FP receptor agonist, inducing phosphoinositide turnover in HEK293 cells expressing the human ocular FP receptor with an EC50 value of 40.2 nM.{11931} Topical application of fluprostenol isopropyl ester (0.01, 0.03, and 0.1 μg) induces miosis in conscious cats in a dose-dependent manner.{9613} It reduces intraocular pressure in a cynomolgus monkey model of ocular hypertension when administered topically at doses of 0.1 and 0.3 μg twice per day. Formulations containing fluprostenol isopropyl ester have been used in the treatment of open-angle glaucoma and ocular hypertension.
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