Formulation: A crystalline solid
Formal Name: 2S-amino-3R-hydroxy-4E-octadecen-1-yl-β-D-galactopyranoside
Purity: ≥95%
Formula Markup: C24H47NO7
Formula Weight: 461,6
Shelf life (days): 1460
CAS Number: 2238-90-6
Notes: Galactosylsphingosine is a bioactive sphingolipid.{32334,32333,15202} It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate (Item No. 10008639).{32334} Galactosylsphingosine (0.1 and 1 µM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes.{32033} Galactosylsphingosine (10 and 15 µM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells.{54403} Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.{32334,32333,15202,54403}[Matreya, LLC. Catalog No. 1305]
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