Geranylgeranoic Acid, CAS 35750-48-2

Formulation: A solution in methyl acetate

Formal Name: (2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenoic acid

Purity: ≥95%

Formula Markup: C20H32O2

Formula Weight: 304,5

Shelf life (days): 730

CAS Number: 35750-48-2

Notes: Geranylgeranoic acid (GGA) is an isoprenoid that has been found in S. chinensis and has anticancer activity.{53890} It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 µM. GGA (10 µM) induces apoptosis in Huh7 cells via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32).{53891} It also inhibits lysine-specific demethylase 1 (LSD1; IC50 = 46.97 µM).{53892}

• SKU: CAY9003474-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 9003474-100
• Green Labware: No
• Package Unit: 100 µg
• Quantity Unit: STK