Formulation: A solid
Formal Name: 13-ethyl-17α-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one-2,2,4,6,6,10-d6
Purity: ≥99% deuterated forms (d1-d6)
Formula Markup: C21H20D6O2
Formula Weight: 316,5
Shelf life (days): 1460
CAS Number: 1542211-40-4
Notes: Gestodene-d6 is intended for use as an internal standard for the quantification of gestodene (Item No. 18217) by GC- or LC-MS. Gestodene is a progestin.{12452} It selectively binds to the progesterone receptor over the estrogen receptor.{61327} Gestodene induces transcriptional activity mediated by the progesterone receptor, and, weakly, the androgen receptor in reporter assays.{61328} It increases the growth of MCF-7 cells when used at concentrations ranging from 0.1 to 1 µM.{61329} In contrast, gestodene (0.1 mg/kg) reduces tumor growth in an estrogen-dependent model of rat mammary tumors induced by DMBA (Item No. 30383). Formulations containing gestodene, in combination with ethynyl estradiol have been used as oral contraceptives.