Formulation: A crystalline solid
Formal Name: 2,3-dihydroxypropyl (2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenamido)ethyl) hydrogen phosphate
Purity: ≥95%
Formula Markup: C25H42NO7P
Formula Weight: 499,6
Shelf life (days): 730
Notes: N-Acylated ethanolamines (NAEs) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl ethanolamide (Item No. 90050) is an endogenous neurotransmitter that evokes cellular responses by activating the cannabinoid (CB) receptors, central CB1 and peripheral CB2. The different types of NAEs are derived from glycerophospho-linked precursors by the activity of glycerophosphodiesterase 1.{15460} Glycerophospho-N-eicosapentaenoyl ethanolamine is the metabolic precursor of eicosapentaenoyl ethanolamide (EPEA; Item No. 10964). EPEA is an NAE that inhibits dietary-restriction-induced lifespan extension in wild type and TOR pathway mutant nematodes.{19623} EPEA also has anti-inflammatory properties, suppressing the expression of IL-6 and MCP-1 in 3T3-L1 adipocytes in response to lipopolysaccharide.{19740}
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