Formulation: A solid
Formal Name: N-[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C26H39D4NO5
Formula Weight: 453,7
Shelf life (days): 1460
CAS Number: 1069132-37-1
Notes: Glycodeoxycholic acid-d4 is intended for use as an internal standard for the quantification of glycodeoxycholic acid (Item No. 20274) by GC- or LC-MS. Glycodeoxycholic acid (GDCA) is a glycine-conjugated form of the secondary bile acid deoxycholic acid (Item Nos. 18231 / 20756).{48223} It induces a reversible, concentration-dependent reduction in myogenic tone in rats and decreases expression of the gene encoding the cytochrome P450 (CYP) isoform 7A1 (CYP7A1) in rabbits.{33912,33913} Serum levels of GDCA are elevated in non-surviving patients with acetaminophen-induced acute liver failure (AALF) compared with survivors.{33914} GDCA levels are also increased in the plasma of patients with asthma.{33911}
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