Formulation: A solid
Formal Name: N-[(3α,5β,7β)-3,7-dihydroxy-24-oxocholan-24-yl-2,2,4,4-d4]-glycine
Purity: ≥99% deuterated forms (d1-d4)
Formula Markup: C26H39D4NO5
Formula Weight: 453,7
Shelf life (days): 730
CAS Number: 2044276-17-5
Notes: Glycoursodeoxycholic acid-d4 (GUDCA-d4) is intended for use as an internal standard for the quantification of GUDCA (Item No. 21698) by GC- or LC-MS. GUDCA is a glycine-conjugated form of the secondary bile acid ursodeoxycholic acid (UDCA; Item No. 15121).{48223,34418} It has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons.{34417,34415} GUDCA reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin (Item No. 17161) in an astroglial cell model of neonatal hyperbilirubinemia.{34416} Oral administration of GUDCA (500 mg/kg per day) decreases the severity of symptoms and increases the amount of A. muciniphila, a commensal bacterial species commonly decreased in patients with inflammatory bowel disease (IBD), in a mouse model of colitis.{34418}
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