Formulation: A crystalline solid
Formal Name: 7-chloro-2',4,6-trimethoxy-6'R-methyl-spiro[benzofuran-2(3H)-1'S-[2]cyclohexene]-3,4'-dione
Purity: ≥98%
Formula Markup: C17H17ClO6
Formula Weight: 352,8
Shelf life (days): 1460
CAS Number: 126-07-8
Notes: Griseofulvin is a polyketide synthase-derived fungal metabolite originally isolated from P. griseofulvum with antifungal and anticancer activities.{60203,31420} It inhibits microtubule assembly when used at concentrations ranging from 20 to 200 µM.{62438} Griseofulvin is active against a variety of dermatophytes (MICs = 0.14-0.42 µg/ml) and reduces the number of infected hair follicles in a guinea pig model of M. canis infection when administered at a dose of 60 mg/kg.{62439,62440} It also reduces viability of a variety of human colorectal cancer cells in vitro and induces abnormal mitotic spindle formation and cell cycle arrest at the G2/M phase in HT-29 cells when used at a concentration of 20 µM.{59871} Griseofulvin (50 mg/kg) reduces tumor growth in a COLO 205 mouse xenograft model. Formulations containing griseofulvin have been used in the treatment of dermatophyte infections of the skin and nails.
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