Hellebrin, CAS 13289-18-4

Formulation: A solid

Formal Name: 3β-[(6-deoxy-4-O-β-D-glucopyranosyl-α-L-mannopyranosyl)oxy]-5β,14-dihydroxy-19-oxo-bufa-20,22-dienolide

Purity: ≥99%

Formula Markup: C36H52O15

Formula Weight: 724,8

Shelf life (days): 1460

CAS Number: 13289-18-4

Notes: Hellebrin is a cardiac glycoside that potently inhibits the Na+/K+-ATPase by binding to it and blocking its non-canonical function as a receptor for cardiac glycosides.{34298,34300} Hellebrin has a higher affinity for the α1β1 subunit of the Na+/K+-ATPase than the α2β1 or α3β1 complexes, in contrast to other cardiac glycosides.{34298} This affinity for the α1β1 complex correlates with its cancer cell growth inhibition (GI50 = 6-58 nM in various human cancer cell lines). Hellebrin also induces caspase-dependent apoptosis in Jurkat T cells.{34299}

• SKU: CAY21442-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 21442-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK