Heptanoyl-Coenzyme A (sodium salt)

Formulation: A solid

Formal Name: S-(2-(3-((2R)-4-(((((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) heptanethioate, sodium salt

Purity: ≥90%

Formula Markup: C28H48N7O17P3S • XNa

Formula Weight: 879,7

Shelf life (days): 1460

Notes: Heptanoyl-coenzyme A (heptanoyl-CoA) is a derivative of CoA (Item Nos. 16147 / 21499 / 21722) that contains the medium-chain fatty acid heptanoic acid (Item No. 33672).{69717} It inhibits butyryl-CoA:acetate-CoA transferase isolated from the gut bacteria P. elsdenii when used at a concentration of 200 µM. Heptanoyl-CoA levels are increased in primary fibroblasts derived from patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in the presence of heptanoic acid, indicating heptanoyl-CoA formation by short-chain acyl-transferases.{69718} It blocks decreases in infarct volume and improvements in motor function induced by the isoquinoline alkaloid berberine (Item No. 10006427) in a mouse model of ischemic stroke induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 0.4 mg/kg per day.{69719}

• SKU: CAY40459-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40459-5
• Package Unit: 5 mg
• Quantity Unit: STK