Formulation: A crystalline solid
Formal Name: 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Purity: ≥98%
Formula Markup: C15H10O7
Formula Weight: 302,2
Shelf life (days): 1460
CAS Number: 527-95-7
Notes: Herbacetin is a natural product that acts as a selective inhibitor of ornithine decarboxylase (ODC).{39081} It inhibits recombinant and HCT116 and HT29 colon cancer cell-derived ODC in a dose-dependent manner while having no effect on 13 tested kinases or S-adenosylmethionine decarboxylase in vitro. Herbacetin suppresses anchorage-independent growth, activation of activator protein-1 (AP-1), a MAP kinase transcription factor, and phosphorylation of ERK1/2 and p90RSK in vitro. It suppresses HCT116 xenograft tumor growth in mice without significant body weight loss when administered i.p. or orally. Herbacetin also inhibits acetylcholinesterase (AChE; IC50 = 1.37 μM) in vitro.{39082}
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