Formulation: A solid
Formal Name: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
Purity: ≥95%
Formula Markup: C16H12O6
Formula Weight: 300,3
Shelf life (days): 1460
CAS Number: 1447-88-7
Notes: Hispidulin is a flavonoid originally isolated from A. montana with diverse biological activities.{45323,45324,45325,45326,45327} It inhibits platelet aggregation induced by platelet-activating factor (PAF), arachidonic acid (Item Nos. 90010 / 90010.1 / 10006607), and ADP (IC50s = 20, 4, and 13 μM, respectively).{45323} Hispidulin inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and bone marrow-derived macrophages (BMMs).{45324} In vivo, hispidulin (25 μg/kg) inhibits LPS-induced bone resorption in mice. It inhibits sphingosine kinase 1 (SPHK1) and induces ceramide accumulation and apoptosis in Caki-2 renal carcinoma cells in vitro and inhibits tumor growth in a Caki-2 mouse xenograft model.{45325} Pretreatment with hispidulin (40 mg/kg) reduces cognitive deficits in the Morris water maze induced by sevoflurane (Item No. 23996) in aged rats.{45326} It also decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury.{45327}
English
Deutsch
