Formulation: A crystalline solid
Formal Name: 3-[(6-deoxy-α-L-mannopyranosyl)oxy]-7-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
Purity: ≥97%
Formula Markup: C33H40O15
Formula Weight: 676,6
Shelf life (days): 1460
CAS Number: 489-32-7
Notes: Icariin is a prenylated flavonoid that has been found in E. pubescens and has diverse biological activities.{64852,64853,64854,64855} It induces the differentiation of ES-D3 embryonic stem cells into cardiomyocytes when used at concentrations of 10 and 100 µM.{64852} Icariin (10 µM) increases the mRNA expression of RUNX family transcription factor 2 (Runx2), osteocalcin (Bgp), and bone sialoprotein (Bsp), gene markers of osteogenesis, in MC3T3-E1 preosteoblast cells.{64853} It reduces IL-6 and TNF-α protein levels induced by LPS in HeLa and RAW 264.7 cells when used at a concentration of 30 µM.{64854} Icariin (0.1 µM) prevents decreases in the levels of the neural integrity markers neurofilament heavy polypeptide (NF-H) and microtubule-associated protein 2 (MAP-2) induced by amyloid-β (1-42) (Aβ42) in primary E18 rat cortical neurons, and it improves spatial memory impairments in the Morris water maze in a 5XFAD transgenic mouse model of Alzheimer's disease when administered at a dose of 34 mg/kg for eight days.{64855}
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