Formulation: A solution in ethanol
Formal Name: 8Z,10E,12Z-octadecatrienoic acid
Purity: ≥95%
Formula Markup: C18H30O2
Formula Weight: 278,4
Shelf life (days): 730
CAS Number: 28872-28-8
Notes: Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants.{30028} Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid (Item No. 90220). Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 µM).{30024,25889,30026} It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress.{25889,30026} Jacaric acid is metabolized in vivo to conjugated linoleic acid (Item No. 90140), which is also cytotoxic to cancer cells.{6849} Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 µM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.{37087,30029}
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