Formulation: A solution in chloroform:methanol:water (2:1:0.1)
Shelf life (days): 730
Notes: Lactosylceramides (LacCers) are endogenous bioactive membrane sphingolipids. They have a role in phagocytosis, chemotaxis, and cell signaling.{41044} LacCer levels are correlated with insulin resistance, obesity, and hyperglycemia in diabetic mice and LacCers enhance neurodegeneration in a mouse model of multiple sclerosis.{41045,27728} Sialogangliosides are membrane sphingolipids composed of sialic acid and oligosaccharide moieties with roles in cell proliferation, differentiation, adhesion, neuronal plasticity, intra- and intercellular signaling, and neurogenesis.{31218,25490,37782} They accumulate in a variety of lysosomal storage disorders including Sandhoff, Tay-Sachs, and Niemann-pick diseases.{40891,43703} Lactosylceramide and Ganglioside GM3 and GD3 Mixture contains LacCers, the monosialoganglioside GM3, and the disialoganglioside GD3. It is intended for use as a reference standard for the detection of LacCers, GM3, and GD3 in various sample types by TLC, LC-, or GC-MS. [Matreya, LLC. Catalog No. 1510]
English
Deutsch
